Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 434, Issue 3, Pages 455-459Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.03.095
Keywords
Adipogenesis; Retinoic acid; Wnt/beta-catenin; Signaling pathways
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Funding
- KRIBB
- Korea National Research Foundation [2010-0022319, 2010-0029305, 2011-0020507, 2011-0030028]
- National Research Foundation of Korea [2011-0030028, 2010-0022319] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Although retinoic acid (RA) is well known to inhibit the differentiation of 3T3-L1 cells into adipocytes both in vivo and in vitro, its molecular mechanism is not fully understood. In this report, we investigate the inhibitory mechanism of adipocyte differentiation by RA in 3T3-L1 cells. Because both RA and Wnt are known to inhibit adipogenesis at a common step involving the inhibition of PPAR-gamma expression, we focused on the crosstalk between these two signaling pathways. We found that RA treatment resulted in a dramatic inhibition of adipogenesis, especially at an early phase of differentiation, and led to increased beta-catenin protein expression. Moreover, RA enhances the transcriptional activity of beta-catenin as well as Wnt gene expression during adipogenesis. Taken together, the present study demonstrated that Wnt/beta-catenin signaling may be associated with the RA-induced suppression of adipogenesis and may cooperatively inhibit adipocyte differentiation. (C) 2013 Elsevier Inc. All rights reserved.
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