Journal
NEUROSCIENCE LETTERS
Volume 305, Issue 1, Pages 29-32Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)01795-5
Keywords
ischaemia; slice culture; hippocampus; excitotoxicity; cytokine; interleukin-1 beta
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Using organotypic hippocampal slice cultures we have investigated the actions of Interleukin-1 (IL-1) in a number of injury paradigms. Low concentrations of IL-1 potentiated hypoxia-induced neurodegeneration whilst high concentrations had no effect. In contrast, higher concentrations of IL-1 were strongly neuroprotective in models of combined oxygen/glucose deprivation and Nmethyl-D-aspartate toxicity, but no potentiation was observed at low IL-1 concentrations. Both protective and toxic effects of IL-1 were fully antagonized by IL-1 receptor antagonist. These data demonstrate that the effects of IL-1 on neutronal injury are complex, and may be directly related to the injury paradigm studied. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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