Journal
SYNLETT
Volume -, Issue 6, Pages 863-865Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2001-14587
Keywords
Biginelli reaction; dihydropyrimidinones; bismuth chloride; one-pot condensation; synthesis
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An efficient synthesis of 3,4-dihydropyrimidines using bismuth chloride as a catalyst from an aldehyde, beta -keto ester and urea in acetonitrile is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of good yields (56-97%).
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