Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 441, Issue 1, Pages 42-46Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.10.014
Keywords
Brown adipocyte; White adipocyte; Beige cell/brite cell/recruitable brown fat cell; Heart-type fatty acid binding protein/fatty acid binding protein 3; Fatty acid oxidation
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Research on Measures for Intractable Diseases from Health and Labour Sciences Research Grants, Subsides to Private Schools
- Vehicle Racing Commemorative Foundation
- Japan Foundation for Applied Enzymology
- Grants-in-Aid for Scientific Research [22126003] Funding Source: KAKEN
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Cold exposure and beta(3)-adrenergic receptor agonist (CL316,243) treatment induce the production of beige cells, which express brown adipocytes(BA)-specific UCP1 protein, in white adipose tissue (WAT). It remains unclear whether the beige cells, which have different gene expression patterns from BA, express BA-characteristic fatty acid oxidation (FAO) proteins. Here we found that 5 day cold exposure and CL316,243 treatment of WAT, but not CL316,243 treatment of primary adipocytes of C57BL/6J mice, increased mRNA levels of BA-characteristic FAO proteins. These results suggest that BA-characteristic FAO proteins are induced in beige cells in a different pathway from UCP1. (C) 2013 Elsevier Inc. All rights reserved.
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