Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 442, Issue 1-2, Pages 1-7Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.09.105
Keywords
Caffeic acid phenethyl ester; Phospholipase D; Glioma cells; Invasion; Proliferation
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Funding
- National Research Foundation of Korea (NRF)
- Korean government (MEST) [2012002009]
- Translational Research Center for Protein Function Control Grant [NSF 2009-0092960]
- Financial Supporting Project of Long-term Overseas Dispatch of PNU's Tenure-track Faculty
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Upregulation of phospholipase D (PLD) is functionally linked with oncogenic signals and tumorigenesis. Caffeic acid phenethyl ester (CAPE) is an active compound of propolis extract that exhibits anti-proliferative, anti-inflammatory, anti-oxidant, and antineoplastic properties. In this study, we demonstrated that CAPE suppressed the expression of PLD1 at the transcriptional level via inhibition of binding of NP kappa B to PLD1 promoter. Moreover, CAPE, but not its analogs, bound to a Cys837 residue of PLD1 and inhibited enzymatic activity of PLD. CAPE also decreased activation of matrix metalloproteinases-2 induced by phosphatidic acid, a product of PLD activity. Ultimately, CAPE-induced downregulation of PLD1 suppressed invasion and proliferation of glioma cells. Taken together, the results of this study indicate that CAPE might contribute to anti-neoplastic effect by targeting PLD1. (C) 2013 Elsevier Inc. All rights reserved.
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