Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 11, Issue 3, Pages 349-356Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-4388(00)00218-X
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Dendritic spines are cellular microcompartments that are isolated from their parent dendrites and neighboring spines. Recently, imaging studies of spine Ca2+ dynamics have revealed that Ca2+ can enter spines through voltage-sensitive and ligand-activated channels, as well as through Ca2+ release from intracellular stores. Relationships between spine Ca2+ signals and induction of various forms of synaptic plasticity are beginning to be elucidated. Measurements of spine Ca2+ concentration are also being used to probe the properties of single synapses and even individual calcium channels in their native environment.
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