Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 187, Issue 3, Pages 283-293Publisher
WILEY-LISS
DOI: 10.1002/jcp.1076
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- NHLBI NIH HHS [HL54269] Funding Source: Medline
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Heparin has long been known to slow the growth of vascular smooth muscle cells. However, the mechanism(s) by which heparin acts has yet to be resolved. The identification of a putative heparin receptor in endothelial cells with antibodies that blocked heparin binding to the cells provided the means to further examine the possible involvement of a heparin receptor in smooth muscle cell responses to heparin. Immunoprecipitation of a smooth muscle cell protein with the antiheparin receptor antibodies provided evidence that the protein was present in smooth muscle cells. Experiments with the anti-heparin receptor antibodies indicate that the antibodies can mimic heparin in decreasing PDGF induced thymidine and BrdU incorporation. The anti-heparin receptor antibodies were also found to decrease MAPK activity levels after activation similarly to heparin. These results support the identification of a heparin receptor and its role in heparin effects on vascular smooth muscle cell growth. J. Cell. Physiol. 187: 283-293, 2001. (C) 2001 Wiley-Liss, Inc.
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