Journal
MOLECULAR CELL
Volume 7, Issue 6, Pages 1131-1141Publisher
CELL PRESS
DOI: 10.1016/S1097-2765(01)00263-5
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Funding
- NIGMS NIH HHS [GM53396, R01 GM053396-11, R01 GM053396, R01 GM053396-12] Funding Source: Medline
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Cvt19 is specifically required for the transport of resident vacuolar hydrolases that utilize the cytoplasmto-vacuole targeting (Cvt) pathway. Autophagy (Apg) and pexophagy, processes that use the majority of the same protein components as the Cvt pathway, do not require Cvt19. Cvt19GFP is localized to punctate structures on or near the vacuole surface. Cvt19 is a peripheral membrane protein that binds to the precursor form of the Cvt cargo protein aminopeptidase I (prAPI) and travels to the vacuole with prAPI. These results suggest that Cvt19 is a receptor protein for prAPI that allows for the selective transport of this protein by both the Cvt and Apg pathways.
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