Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 433, Issue 4, Pages 563-566Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.03.031
Keywords
TGR5; Human adipose tissue; Gene expression; Obesity; Resting metabolic rate
Categories
Funding
- Wellcome Trust [GR079534]
- Swedish Foundation for Strategic Research, Sahlgrenska Center for Cardiovascular and Metabolic Research
- Swedish Childhood Cancer Foundation
- Swedish federal government under the LUA/ALF agreement
- MRC [G1002084] Funding Source: UKRI
- Medical Research Council [G1002084] Funding Source: researchfish
Ask authors/readers for more resources
Bile acids have emerged as a new class of signaling molecules that play a role in metabolism. Studies in mice have shown that the bile acid receptor TGR5 mediates several of these effects but the metabolic function of TGR5 in humans is less well established. Here we show that human adipose tissue TGR5 expression is positively correlated to obesity and reduced during diet-induced weight loss. Adipose tissue TGR5 expression was also positively correlated to resting metabolic rate. Our study indicates that human adipose tissue contributes to the TGR5 mediated metabolic effects of bile acids and plays a role in energy expenditure. (C) 2013 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available