Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 436, Issue 1, Pages 90-95Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.05.064
Keywords
TRIM39B; TRIM39R; RPP21; Type I interferon response; Defense of viral infection; Behcet's disease
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Funding
- Tokai University School of Medicine Research Aid, Health Labour Sciences Research Grant, Japanese Research Committee of Behcet's Disease, Research on Measures for Intractable Disease [200]
- Japan Society for Promotion of Science [JSPS-12J07231, JSPS-25830062]
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Behcet's disease (BD) is a chronic relapsing inflammatory autoimmune disease characterized by recurrent oral and genital ulcers, skin legions and uveitis and its pathogenesis is not fully elucidated. Previously we identified that two novel susceptible SNPs are associated with BD. One is located in putative RNF39 promoter region, another is located on TRIM39 coding exon. In this study, in order to identify the molecular function of TRIM39, we established gain-of-function of TRIM39 related genes and thus, performed microarray analysis. Our results indicate that TRIM39R, but not TRIM39B, regulates type I interferon response. (C) 2013 Elsevier Inc. All rights reserved.
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