Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 430, Issue 2, Pages 676-682Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2012.11.092
Keywords
Exercise; Insulin; Islet; Beta-cell; Type 1 diabetes; Skeletal muscle; Perifusion assay
Categories
Funding
- Japan Society for the Promotion of Science [KAKENHI 21700657, KAKENHI 21240063]
- Cabinet Office, Government of Japan (Funding Program for Next Generation World-Leading Researchers) [LS102]
- Grants-in-Aid for Scientific Research [24700700] Funding Source: KAKEN
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We evaluated the effect of chronic exercise on insulin secretion in response to high-glucose by using a perifusion method with isolated pancreatic islets from normal rats. Male Wistar rats were assigned to one of two groups: a sedentary group and a trained group. Running exercise was carried out on a treadmill for one hour per day, five days per week, for six, nine, or 12 weeks. The chronic exercise significantly enhanced the insulin secretion ability of pancreatic islets in response to the high-glucose stimulation upon nine and 12 weeks of exercise. The insulin content in the pancreas and the weight of the pancreas did not change upon nine weeks of exercise. Potassium-stimulated insulin secretion was also increased in the islets isolated from rats that trained for nine weeks compared with that in sedentary rats, suggesting that insulin secretion events downstream of membrane depolarization are involved in targets of the exercise effect. These findings suggest that chronic exercise could be a useful strategy not only for the maintenance of peripheral insulin sensitivity but also for the promotion of islet function to secrete insulin in non-diabetics. (C) 2012 Elsevier Inc. All rights reserved.
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