Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 433, Issue 4, Pages 396-400Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.02.082
Keywords
Angiogenesis; Mitochondria; UQCRB; Zebrafish
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Funding
- National Research Foundation (NRF) of Korea
- Korean Government (MEST) [2009-0092964, 2010-0017984, 2012M3A9D1054520]
- Translational Research Center for Protein Function Control
- National Junior Research Fellowship, NRF [2009-0083522, 2011-006165]
- Center for Food and Drug Materials of Agriculture Science & Technology Development [PJ0079772012]
- Rural Development Administration
- Brain Korea 21 Project
- National Institutes of Health [DP1 HD075622]
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As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases. (C) 2013 Elsevier Inc. All rights reserved.
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