Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 441, Issue 4, Pages 880-885Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.10.156
Keywords
High density lipoprotein; Low density lipoprotein; Chenodeoxycholic acid; Cholesterol ester transfer protein; Apolipoprotein F
Categories
Funding
- National Natural Science Foundation of China [81070228, 81270363]
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Apolipoprotein F is a component protein mainly secreted by liver and resides on several lipoprotein classes. It can inhibit lipids transfer between different lipoproteins. FXR is a member of the nuclear receptor superfamily which is also highly expressed in the liver. It modulates bile acids synthesis and lipids metabolism by transcriptional regulation. We aimed to determine whether apoF can be regulated by FXR. The FXR agonist Chenodeoxycholic acid (CDCA) and GW4064 both can activate the expression of apoF in liver cell lines and in C57/BL6 mouse liver. This is dependent on the binding of FXR to the FXR element ER1 (-2904 to -2892 bp) in the apoF gene promoter. Taken together, we have identified apoF as likely another target gene of FXR. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
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