Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 1, Issue 6, Pages 1037-1048Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-5769(01)00035-2
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Increased progesterone sensitivity of pregnancy lymphocytes is due to activation-induced appearance of progesterone binding sites in the lymphocytes. Following recognition of fetally derived antigens; gamma/delta TCR+ cells develop progesterone receptors. Progesterone binding results in the synthesis of a mediator protein named the progesterone-induced blocking factor (PIBF). PIBF by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect. (C) 2001 Elsevier Science B.V. All rights reserved.
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