Journal
EMBO REPORTS
Volume 2, Issue 6, Pages 530-535Publisher
OXFORD UNIV PRESS
DOI: 10.1093/embo-reports/kve110
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Funding
- NCRR NIH HHS [R24 RR012596, RR12596] Funding Source: Medline
- NIDDK NIH HHS [DK55526, R01 DK055526, DK99-012] Funding Source: Medline
- NIH HHS [R24 OD010943] Funding Source: Medline
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The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the exc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysis suggests that exc-5 is required for the proper placement of cytoskeletal elements at the apical epithelial surface. exc-5 encodes a protein homologous to guanine nucleotide exchange factors and contains motif architecture similar to that of FGD1, which is responsible for faciogenital dysplasia. exc-5 interacts genetically with mig-2 which encodes Rho GTPase. These results suggest that EXC-5 controls the structural organization of the excretory canal by regulating Rho family GTPase activities.
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