Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 11, Issue 3, Pages 309-314Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(00)00206-2
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Large RNAs often have rugged folding energy landscapes that result in severe misfolding and slow folding kinetics, Several interdependent parameters that contribute to misfolding are now well understood and examples of targe RNAs and ribonucleoproteins that avoid kinetic traps have been reported. These advances have facilitated the exploration of fundamental RNA folding processes that were previously inaccessible.
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