Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 427, Issue 2, Pages 280-284Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2012.09.039
Keywords
Acute myocardial infarction; Circulating microRNAs; Secondary prevention
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Funding
- Japanese Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan [19590816, 19390215]
- Grants-in-Aid for Scientific Research [19390215, 19590816] Funding Source: KAKEN
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To investigate the prognostic impact of circulating microRNAs (miRs) in patients who survived acute myocardial infarction (AMI), we compared the circulating miR signature at the time of survival discharge among samples in the serum bank of the Osaka Acute Coronary Insufficiency Study. Using a high-throughput array consisting of 667 miRs, 11 miRs were found to be differentially expressed in the serum among patients at high-risk for cardiac death. Real-time RT-PCR confirmed that the serum levels of miR-155 and miR-380* were approximately 4- and 3-fold higher, respectively, in patients who experienced cardiac death within 1 year after discharge. Accordingly, a subset of circulating miRs might be predictive for cardiac death in post-AMI patients. (C) 2012 Elsevier Inc. All rights reserved.
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