Journal
SEXUALLY TRANSMITTED INFECTIONS
Volume 77, Issue 3, Pages 199-201Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/sti.77.3.199
Keywords
HIV; seroconverting illness; neurocognitive impairment
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Funding
- NIMH NIH HHS [MH 45294] Funding Source: Medline
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Objectives: To establish whether symptomatic seroconverting illness in HIV infected people is associated with more rapid development of neurological impairment. Methods: 166 HIV infected subjects with a known date of HIV infection enrolled in a longitudinal study of neurocognitive function were stratified by whether or not they had experienced a symptomatic serconverting illness. Results: 29 of 166 (17.5%) dated HIV seroconverters had a history of symptomatic seroconverting illness. Though baseline neurocognitive function was similar, subjects with a symptomatic seroconverting illness developed clinical neurocognitive impairment significantly more rapidly than their asymptomatic counterparts in a survival analysis model (636 v 1075 days till impaired). Conclusion: Symptomatic seroconverting illness predisposes to more rapid neurocognitive impairment.
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