Journal
BIOMATERIALS
Volume 22, Issue 12, Pages 1599-1606Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(00)00312-4
Keywords
bone substitute; risk analysis; bovine spongiform encephalopathy; Western blot
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Bone substitutes of bovine origin are widely used for treatment of bone defects in dental and orthopedic surgery. Due to the occurrence of BSE and the new variant of Creutzfeldt Jakob Disease risks of transmitting diseases through the use of such materials need to be carefully evaluated. Risk analysis can either be based on theoretical assessments or experimental evidence. Here we present a comparative study on two bovine bone substitutes (Bio-Oss(R) and Osteograf/N) which is based on theoretical values. Furthermore, for one of these materials, i.e. Bio-Oss(R), the prion inactivation capacity of one of the production steps was experimentally evaluated. Theoretical and experimental data indicate that the use of these materials does not carry a risk of transmitting BSE to patients. (C) 2001 Elsevier Science Ltd. All rights reserved.
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