Journal
JOURNAL OF FLUORINE CHEMISTRY
Volume 109, Issue 1, Pages 87-94Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/S0022-1139(01)00382-7
Keywords
hypotensive preparations; fluorine-containing substituents; calcium and potassium channels modulators; angiotensin II receptor antagonists; benzimidazole
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The synthesis and pharmacological properties of a novel type of vasorelaxant hybrid compounds are described. The investigated compounds are based on fluorinated 4-aryl-1,4-dihydropyridines (1,4-DHP), which are known calcium channel blockers, and/or from fluorinated analogues of pinacidil, an opener of ATP-sensitive potassium channels. Benzimidazole analogues of hypotensive preparation losartan with fluorine-containing substituents in positions 2 and 5, as well as at heterocyclic nitrogen atom of benzimidazole ring are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.
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