Journal
EUROPEAN JOURNAL OF SURGICAL ONCOLOGY
Volume 27, Issue 4, Pages 340-342Publisher
W B SAUNDERS CO LTD
DOI: 10.1053/ejso.2000.1040
Keywords
hyperthermia; hypoxia; intra-arterial chemotherapy; tirapazamine
Ask authors/readers for more resources
It has been demonstrated in vitro and in vivo that hyperthermia can enhance the cytotoxicity of some chemotherapeutic agents. The in vivo studies have demonstrated that the thermal advantage is maximized at mild temperatures such: as at 40.5-13 degreesC. Thermo-chemotherapy is widely applied in limb perfusion and intraperitoneal chemotherapy. Hypoxia in solid tumours leads to resistance to most anticancer drugs and appears to accelerate malignant progression and increase metastasis. The recent development of new drugs highly toxic to hypoxic cells may bring new strategies in anticancer treatments and move this condition from being a problem to a new tool in cancer control. (C) 2001 Harcourt Publishers Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available