Five novel oligostilbenes from the roots of Caragana sinica

One novel resveratrol trimer, caraphenol A (1), and four novel resveratrol dimers, (+)-isoampelopsin F (2), caraphenol B (3), C (4), (-)-ampelopsin F (5) were isolated from the roots of C. sinica. Their structures and stereochemistry were elucidated by means of spectroscopic evidence, especially HMBC and NOE experiments. The pharmacological activities in anti-HIV of all compounds and stimulation of osteoblast growth tests of the EtOAc extract of the roots of C. sinica have been determined. (C) 2001 Elsevier Science Ltd. All rights reserved.