Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 423, Issue 2, Pages 344-349Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2012.05.127
Keywords
Hyaluronan; Chondroitin; Glycosaminoglycan; Hyaluronidase; Transglycosylation
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [19570119, 23570157]
- Fund for Cooperation for Innovative Technology and Advanced Research in an Evolution Area (City Area)
- Sun-star Inc. (Osaka, Japan)
- Grants-in-Aid for Scientific Research [23570157, 23650253, 19570119] Funding Source: KAKEN
Ask authors/readers for more resources
Hyaluronan and chondroitin are glycosaminoglycans well-known as components of pharmaceutical agents and health foods. From these attractive molecules, using transglycosylation reaction of testicular hyaluronidase, we synthesized hybrid neo-oligosaccharides not found in nature. We also found a new site between the chondroitin disaccharide unit and hyaluronan disaccharide unit recognized by a hyaluronan lyase specific to hyaluronan using these hybrid oligosaccharides as substrates. We hope that these hybrid oligosaccharides will help to elucidate the involvement of hyaluronan, chondroitin, and chondroitin sulfates in the mechanisms of cell functions and diseases, based on the structures of these glycosami noglycans. (C) 2012 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available