Journal
JOURNAL OF IMMUNOLOGY
Volume 166, Issue 12, Pages 7477-7485Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.166.12.7477
Keywords
-
Categories
Ask authors/readers for more resources
IL-12 is a key cytokine in directing the development of type I Th cells, which are critical to eradicate intracellular pathogens such as Mycobacterium tuberculosis. Here, we report that mannose-capped lipoarabinomarmans (ManLAMs) from Mycobacterium bovis bacillus Calmette-Guerin and Mycobacterium tuberculosis inhibited, in a dose-dependant manner, the LPS-induced IL-12 production by human dendritic cells. The inhibitory activity was abolished by the loss of the mannose caps or the GPI acyl residues. Mannan, which is a ligand for the mannose receptor (MR) as well as an mAb specific for the MR, also inhibited the LPS-Induced IL-12 production by dendritic cells. Our results indicate that ManLAMs may act as virulence factors that contribute to the persistence of M. bovis bacillus Calmette-Guerin and M. tuberculosis within phagocytic cells by suppressing IL-12 responses. Our data also suggest that engagement of the MR by ManLAMs delivers a negative signal that interferes with the LPS-induced positive signals delivered by the Toll-like receptors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available