Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 409, Issue 2, Pages 308-314Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2011.05.008
Keywords
Caloric restriction; Mitochondrial electron transport chain; Reactive oxygen species; Mitochondrial membrane potential; Growth rate; Lifespan extension
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Funding
- Korea Government (MEST) [2008-0061063, 2009-0084110, 351-2009-1-C00063]
- National Research Foundation of Korea [2008-0061063, 2006-2005313, 351-2009-1-C00063] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Caloric restriction (CR) is known to extend lifespan in a variety of species; however, the mechanism remains unclear. In this study, we found that CR potentiated the mitochondrial electron transport chain (ETC) at both the transcriptional and translational levels. Indeed, mitochondrial membrane potential (MMP) was increased by CR, and, regardless of ages, overall reactive oxygen species (ROS) generation was decreased by CR. With these changes, overall growth rate of cells was maintained under various CR conditions, just like cells under a non-restricted condition. All of these data support increased efficiency and capacity of the ETC by CR, and this change might lead to extension of lifespan. (C) 2011 Elsevier Inc. All rights reserved.
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