Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 411, Issue 4, Pages 714-720Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2011.07.010
Keywords
Proteomics; Bladder cancer; Urinary protein; Protein identification; Biomarker
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Funding
- National Science Council [NSC97-2320-B-037-012-MY3, NSC-099-2811-E-224-002]
- Chi-Mei Medical Center-Kaohsiung Medical University Research Foundation [98CM-KMU-01]
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Human urine contains a large number of proteins and peptides (the urinary proteome). Global analysis of the human urinary proteome is important for understanding urinary tract diseases. Bladder cancer is the most common urological cancer with higher incidence rates in endemic areas of Blackfoot disease (BFD) in southern Taiwan. The aim of this study was to use the proteomic approach to establish urinary protein biomarkers of bladder cancer. ADAM28, identified by proteomic approaches and confirmed by Western blotting, showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer. (C) 2011 Elsevier Inc. All rights reserved.
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