Phosphatidylinositol 4-phosphate 5-kinase Iγ_v6, a new splice variant found in rodents and humans

Phosphatidylinositol 4-phosphate 5-kinase I gamma (PIP5KI gamma) is subject to extensive C-terminal splice variation, with four variants, PIP5KI gamma_v1, 2,4 and 5, described in humans Schill and Anderson (2009)17]. Here firstly, we report a new rodent splice variant, which includes the exon that was previously unique to the rodent neuron-specific PIP5KI gamma 93 Giudici et al. (2006) [6], but which omits the C-terminal exon of P1P5KI gamma 93; this new variant shows a wide tissue expression pattern in mouse. Secondly, we show that in humans there is an alternative splicing site 78 nucleotides from the start of exon 16c, such that humans additionally express both PIP5KI gamma 93 (which we now call PIP5KI gamma_v3) specifically in brain and, again expressed more widely, the new variant described here, which we now name PIP5KI gamma_v6. (C) 2011 Elsevier Inc. All rights reserved.