Journal
MOLECULAR BRAIN RESEARCH
Volume 90, Issue 2, Pages 202-204Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(01)00093-6
Keywords
methamphetamine; gene expression; c-myc; L-myc; apoptosis
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To clarify the possible mechanisms by which the recreational drug, methamphetamine (METH), induces apoptosis, we investigated its effects on the expression of Myc apoptotic genes. This paper presents the characterization of c-myc and L-myc gene transcription in the striatum and the cortex. In addition, the expression of the corresponding proteins was also evaluated. Our observations reveal that c-myc and L-myc were up-regulated by METH at both the mRNA and protein levels. Thus, myc transcription factors might be responsible for some aspects of METH-induced apoptotic processes.
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