Journal
NEUROSCIENCE LETTERS
Volume 306, Issue 1-2, Pages 132-134Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)01871-7
Keywords
migraine; evoked potentials; auditory P50; sensory gating; cortical processing; habituation
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Habituation of cortical evoked responses to repetitive stimuli is reduced in migraine between attacks. To explore another aspect of information processing, we measured auditory sensory gating. The amplitude of the P50 response to the second of two homologous stimuli was significantly less reduced in migraineurs than in healthy volunteers. This lack of auditory sensory gating may be due to a hypofunction of monoaminergic subcortico-cortical pathways, which is also supposed to cause the interictal deficit of cortical habituation to repetitive stimuli. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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