Journal
LANCET
Volume 357, Issue 9273, Pages 2023-2024Publisher
LANCET LTD
DOI: 10.1016/S0140-6736(00)05108-4
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Funding
- NCI NIH HHS [CA11051] Funding Source: Medline
- NHLBI NIH HHS [HL36543, HL56002] Funding Source: Medline
- NIDCR NIH HHS [DE11390] Funding Source: Medline
- NIEHS NIH HHS [ES01247] Funding Source: Medline
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Febrile responses are a common and sometimes life-threatening occurrence in patients receiving platelet transfusions. The cause is largely unknown. We showed that CD154 is present at 3000-7000 ng/L in the supernatant of nine preparations of human platelets used for transfusions and induces prostaglandin E-2 synthesis in human fibroblasts. Since CD154 is a potent Inducer of the cyclo-oxygenase-2 enzyme and prostaglandin E-2, the main fever inducers, infusion of platelet preparations containing CD154 may incite febrile responses.
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