Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 407, Issue 1, Pages 60-62Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2011.02.103
Keywords
Warfarin; Time resolved fluorescence spectroscopy; Time correlated single photon counting; Human serum albumin; Sudlow I; Molecularly imprinted polymer; MIP
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Funding
- Swedish Research Council (V.R.)
- Knowledge Foundation (K.K.S.)
- Carl Tryggers Foundation
- Linnaeus University
- Uppsala University
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Here we report on a novel method for the direct in situ measurement of specific isomeric forms of the anticoagulant warfarin using time correlated single-photon counting (TCSPC) spectroscopy in conjunction with synthetic Sudlow I binding site receptors. The method is highly robust over the clinically significant concentration range, and demonstrates the potential of the binding site mimics in conjunction with the spectroscopic strategy employed here for the determination of this important pharmaceutical in clinical or even environmental samples. (C) 2011 Elsevier Inc. All rights reserved.
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