Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 405, Issue 2, Pages 186-191Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2011.01.006
Keywords
Autophagy; Pentagalloylglucose (PGG); HSV-1 infections; Anti-viral activity
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Funding
- National Science Foundation of China [U0632010]
- State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences [P2008-KF07, P2008-ZZ08]
- Ministry of Education (MOE) [211]
- Fundamental Research Funds for the Central Universities
- Tokyo Biochemical Research Foundation
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22590274]
- Grants-in-Aid for Scientific Research [22590274] Funding Source: KAKEN
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Pentagalloylglucose (PGG) is a natural polyphenolic compound with broad-spectrum anti-viral activity, however, the mechanisms underlying anti-viral activity remain undefined. In this study, we investigated the effects of PGG on anti-viral activity against Herpes simplex virus type 1 (HSV-1) associated with autophagy. We found that the PGG anti-HSV-1 activity was impaired significantly in MEF-atg7(-/-) cells (autophagy-defective cells) derived from an atg7(-/-) knockout mouse. Transmission electron microscopy revealed that PGG-induced autophagosomes engulfed HSV-1 virions. The mTOR signaling pathway, an essential pathway for the regulation of autophagy, was found to be suppressed following PGG treatment. Data presented in this report demonstrated for the first time that autophagy induced following PGG treatment contributed to its anti-HSV activity in vitro. (C) 2011 Elsevier Inc. All rights reserved.
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