Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 5, Issue 3, Pages 221-239Publisher
WILEY
DOI: 10.1111/j.1582-4934.2001.tb00157.x
Keywords
apoptosis; 4E-binding proteins; eIF4E; mTOR; protein kinases; protein synthesis; stress; translational control
Categories
Ask authors/readers for more resources
Several mechanisms have been identified by which protein synthesis may be regulated during the response of mammalian cells to physiological stresses and conditions that induce apoptotic cell death (reviewed in Clemens et al., Cell Death and Differentiation 7, 603-615, 2000). Recent developments allow us to up-date this analysis and in this article I concentrate on one particular aspect of this regulation that has not previously been reviewed in depth in relation to apoptosis, viz. the control of the initiation of protein synthesis by eukaryotic initiation factor eIF4E and the eIF4E binding proteins (4E-BPs). Changes in the state of phosphorylation of the 4E-BPs and in the extent of their association with eIF4E occur at an early stage in the response of cells to apoptotic inducers. The review discusses the mechanisms by which these events are regulated and the significance of the changes for the control of protein synthesis, cell proliferation and cell survival.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available