Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 391, Issue 4, Pages 1775-1779Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.12.154
Keywords
Autophagy; Chitin; Chitosan; Glucosamine; Hexosamine; Polyglutamine disease
Categories
Funding
- Programme for Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry
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Autophagy is a cellular process that nonspecifically degrades cytosolic components and is involved in many cellular responses. We found that amino sugars with a free amino group such as glucosamine, galactosamine and mannosamine induced autophagy via an rnTOR-independent pathway. Glucosamine-induced autophagy at concentrations of at least 500 mu M to over 40 mM. In the presence of 40 mM glucosamine, autophagy induction was initiated at 6 h and reached a plateau at 36 h. Glucosamine-induced autophagy could remove accumulated ubiquitin-conjugated proteins as well as 79-glutamine repeats. Therefore, Orally administered glucosamine could contribute to the prevention of neurodegenerative diseases and promotion of antiaging effects. (C) 2010 Elsevier Inc. All rights reserved.
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