Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 392, Issue 3, Pages 271-276Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.12.163
Keywords
Acute myeloid leukemia; Leukemic stem cell; Microenvironment; Cell adhesion; Glycophorin A; CD44
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Funding
- Waseda University [2008A-875]
- Chugai Pharmaceutical Co., Ltd [17209020]
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For long-term survival in vitro and in vivo of acute myeloid leukemia cells. their adhesion to bone marrow stromal cells is indispensable However, it is still unknown if these events are uniquely induced by the leukemic stem cells Here we show that TF-1 human leukemia cells, once they have formed a cobblestone area by adhering to mouse bone marrow-derived MS-5 cells, can acquire some leukemic stem cell like properties in association with a change in the CD44 isoform-expression pattern and with an increase in a set of related microRNAs These findings strongly suggest that at least some leukemia cells can acquire leukemic stem cell like properties in an adhesion-mediated stochastic fashion (C) 2010 Elsevier Inc. All rights reserved
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