Journal
INTERNATIONAL JOURNAL OF HEMATOLOGY
Volume 74, Issue 1, Pages 76-78Publisher
CARDEN JENNINGS PUBL CO LTD
DOI: 10.1007/BF02982553
Keywords
secondary amyloidosis; Waldenstrom's macroglobulinemia; nephrotic syndrome
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It is widely accepted that amyloidosis in Waldenstrom's macroglobulinemia (WM) is exclusively due to amyloid light-chain deposition. However, only a small number of previous reports have actually characterized the type of amyloid in WM. We now report the third patient with WM and amyloid A protein (AA) amyloidosis. This patient developed malabsorption, nephrotic syndrome, and orthostatic hypotension. AA was immunohistochemically demonstrated in the rectal biopsy. In conjunction with previous examples of AA amyloidosis, the present report raises the possibility that AA amyloidosis may also occur in WM patients. (C) 2001 The Japanese Society of Hematology.
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