Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 394, Issue 1, Pages 200-204Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.02.155
Keywords
Biosensor; Influenza virus; Oligosaccharide probe; Fluorescent; Click chemistry
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Funding
- New Energy and Industrial Technology Development Organization (NEDO)
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Japanese Society for the Promotion of Sience (JSPS)
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Tetraphenylethylene (TPE) derivatives have strong fluorescence in aggregated state. We designed and synthesized a tetraphenylethylene derivative bearing alkyne groups which were used for combination by click chemistry. The new TPE compound bearing alkyne groups was used to synthesize fluorescence oligosaccharide probes which have lactosyl and 6'-sialyllactosyl moieties as ligands. We found that the TPE compounds bearing lactosyl and 6'-sialyllactosyl moieties were useful for detection of RCA120 and SSA lectins, respectively. Moreover, we have shown that TPE-based fluorescent oligosaccharide probe bearing 6'-sialyllactose moiety can be utilized as a turn-on fluorescent sensor for detection of influenza virus. (C) 2010 Elsevier Inc. All rights reserved.
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