Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 401, Issue 4, Pages 521-526Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.09.080
Keywords
luxS; Microarrays; Flagella; Motility; Network Component Analysis; Escherichia coli
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Funding
- Ministry of Education of Singapore (AcRF) [RG31/07]
- National Medical Research Council of Singapore [NIGO7NOV035]
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Despite the significant role of S-ribosylhomocysteinase (LuxS) in the activated methyl cycle pathway and quorum sensing the connectivity between luxS and other cellular functions remains incomplete Herein we show that luxS deletion significantly increases swimming motility and flagella synthesis in Escherichia colt K12 using motility transcriptome and scanning electron microscopy assays Further based on the transcriptome and network component analyses and known regulatory relations we propose a conceptual genetic regulatory network underlying the increased flagella synthesis in response to luxS deletion (C) 2010 Elsevier Inc All rights reserved
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