Related references
Note: Only part of the references are listed.APLP1 and APLP2, members of the APP family of proteins, behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression
Sarah L. Cousins et al.
JOURNAL OF NEUROCHEMISTRY (2015)
Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and Function
Rachel M. Devay et al.
PLOS ONE (2015)
Reduction of Low-Density Lipoprotein Cholesterol by Monoclonal Antibody Inhibition of PCSK9
Evan A. Stein et al.
ANNUAL REVIEW OF MEDICINE, VOL 65 (2014)
Sorting an LDL receptor with bound PCSK9 to intracellular degradation
Trond P. Leren
ATHEROSCLEROSIS (2014)
The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion
Camilla Gustafsen et al.
CELL METABOLISM (2014)
PCSK9: A Key Modulator of Cardiovascular Health
Nabil G. Seidah et al.
CIRCULATION RESEARCH (2014)
Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia and other Pathologies
Nabil G. Seidah
CURRENT PHARMACEUTICAL DESIGN (2013)
Characterization of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Trafficking Reveals a Novel Lysosomal Targeting Mechanism via Amyloid Precursor-like Protein 2 (APLP2)
Rachel M. DeVay et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
The Intracellular Domain of Sortilin Interacts with Amyloid Precursor Protein and Regulates Its Lysosomal and Lipid Raft Trafficking
Miao Yang et al.
PLOS ONE (2013)
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)
Maryssa Canuel et al.
PLOS ONE (2013)
SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion
Xiao-Wei Chen et al.
ELIFE (2013)
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia
Marianne Abifadel et al.
ATHEROSCLEROSIS (2012)
Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9
Javier Chaparro-Riggers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
The M2 Module of the Cys-His-rich Domain (CHRD) of PCSK9 Protein Is Needed for the Extracellular Low-density Lipoprotein Receptor (LDLR) Degradation Pathway
Yascara Grisel Luna Saavedra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Loss- and Gain-of-function PCSK9 Variants CLEAVAGE SPECIFICITY, DOMINANT NEGATIVE EFFECTS, AND LOW DENSITY LIPOPROTEIN RECEPTOR (LDLR) DEGRADATION
Suzanne Benjannet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR
Yan Wang et al.
JOURNAL OF LIPID RESEARCH (2012)
The biology and therapeutic targeting of the proprotein convertases
Nabil G. Seidah et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase
Gregory Neveu et al.
METHODS (2012)
Circulating Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Regulates VLDLR Protein and Triglyceride Accumulation in Visceral Adipose Tissue
Anna Roubtsova et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)
Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH
Paola Lo Surdo et al.
EMBO REPORTS (2011)
In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9
Rachid Essalmani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Benchmarking a luciferase complementation assay for detecting protein complexes
Patricia Cassonnet et al.
NATURE METHODS (2011)
Effects of the Prosegment and pH on the Activity of PCSK9 EVIDENCE FOR ADDITIONAL PROCESSING EVENTS
Suzanne Benjannet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Disrupted recycling of the low density lipoprotein receptor by PCSK9 is not mediated by residues of the cytoplasmic domain
Thea Bismo Strom et al.
MOLECULAR GENETICS AND METABOLISM (2010)
New Insights into the Structural Mechanisms of the COPII Coat
Christopher Russell et al.
TRAFFIC (2010)
Degradation of LDLR protein mediated by 'gain of function' PCSK9 mutants in normal and ARH cells
Tommaso Fasano et al.
ATHEROSCLEROSIS (2009)
The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes
Jibin Zeng et al.
EXPERIMENTAL CELL RESEARCH (2009)
Mechanism for Amyloid Precursor-like Protein 2 Enhancement of Major Histocompatibility Complex Class I Molecule Degradation
Amit Tuli et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells
Markey C. McNutt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation EVIDENCE FOR AN INTRACELLULAR ROUTE
Steve Poirier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Proprotein convertase Subtilisin/Kexin type 9 (PCSK9): Hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration
Ahmed Zaid et al.
HEPATOLOGY (2008)
Amyloid precursor-like protein 2 increases the endocytosis, instability and turnover of the H2-Kd MHC class I molecule
Amit Tuli et al.
JOURNAL OF IMMUNOLOGY (2008)
Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
Da-Wei Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
Steve Poirier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Pernille Jansen et al.
NATURE NEUROSCIENCE (2007)
Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells
Markey C. McNutt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation
Timothy S. Fisher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR
Nasha Nassoury et al.
TRAFFIC (2007)
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia
David Cunningham et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly
Oystein L. Holla et al.
BMC CELL BIOLOGY (2007)
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
Thomas A. Lagace et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse
R Essalmani et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
C Jonathan et al.
NATURE GENETICS (2005)
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
G Dubuc et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)
Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
SW Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
NARC-1/PCSK9 and its natural mutants -: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
S Benjannet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Bi-directional protein transport between the ER and Golgi
MCS Lee et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2004)
Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype
KN Maxwell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
M Abifadel et al.
NATURE GENETICS (2003)
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1):: Liver regeneration and neuronal differentiation
NG Seidah et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2
GC He et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
ER-associated degradation in protein quality control and cellular regulation
RY Hampton
CURRENT OPINION IN CELL BIOLOGY (2002)
Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein
CK Garcia et al.
SCIENCE (2001)
The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein
MS Nielsen et al.
EMBO JOURNAL (2001)
Post-translational processing of β-secretase (β-amyloid-converting enzyme) and its ectodomain shedding -: The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-β production
S Benjannet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)