Journal
JOURNAL OF BACTERIOLOGY
Volume 183, Issue 13, Pages 4099-4102Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.183.13.4099-4102.2001
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- NIAID NIH HHS [AI22223] Funding Source: Medline
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PCR mutagenesis and a unique enrichment scheme were used to obtain two mutants, each with a single lesion in fimH, the chromosomal gene that encodes the adhesin protein (FimH) of Escherichia coli type 1 pill, These mutants were noteworthy in part because both were altered in the normal range of cell types bound by FimH, One mutation altered an amino acid at a site previously shown to be involved in temperature-dependent binding, and the other altered an amino acid lining the predicted FimH binding pocket.
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