Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 396, Issue 3, Pages 703-708Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.04.165
Keywords
Cell adhesion molecule 1 (CADM1); Social behavior; Anxiety-related behavior; Motor function; Autism
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Funding
- MEXT [20590237, 20020023, 20790194, 22120512, 22659050]
- JSPS
- Grants-in-Aid for Scientific Research [22659050, 22591135, 20790194, 22120512, 20590237, 20020023] Funding Source: KAKEN
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Cell adhesion molecule 1 (CADM1), a member of the immunoglobulin superfamily, mediates synaptic cell adhesion. Missense mutations in the CADM1 gene have been identified in autism spectrum disorder (ASD) patients. In the present study, we examined emotional behaviors, social behaviors and motor performances in Cadm1-knockout (KO) mice. Cadm1-KO mice showed increased anxiety-related behavior in open-field and light-dark transition tests. Social behaviors of Cadm1-KO mice were impaired in social interaction, resident-intruder and social memory/recognition tests. Furthermore, motor coordination and gait of Cadm1-MO mice were impaired in rotarod and footprint tests. Our study demonstrates that CADM1 plays roles in regulating emotional behaviors, social behaviors and motor performances, and that CADM1 has important implications for psychiatric disorders with disruptions in social behavior, such as autism. (C) 2010 Elsevier Inc. All rights reserved.
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