Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 395, Issue 3, Pages 377-381Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.04.024
Keywords
Phospholipase A(2); Phospholipase A(2) inhibitor; Viperidae; Gene expression; Snake venom; Self-protection
Categories
Ask authors/readers for more resources
Venomous snakes such as Gloydius brevicaudus have three distinct types of phospholipase A(2) inhibitors (PLI alpha, PLI beta, and PLI gamma) in their blood so as to protect themselves from their own venom phospholipases A(2) (PLA(2)s). Expressions of these PLIs in G. brevicaudus liver were found to be enhanced by the intramuscular injection of its own venom. The enhancement of gene expressions of PLI alpha and PLI beta in the liver was also found to be induced by acidic PLA(2) contained in this venom. Furthermore, these effects of acidic PLA(2) on gene expression of PLIs were shown to be unrelated to its enzymatic activity. These results suggest that these venomous snakes have developed the self-protective system against their own venom, by which the venom components up-regulate the expression of anti-venom proteins in their liver. (C) 2010 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available