Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 391, Issue 1, Pages 142-146Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.11.020
Keywords
E2F repression; HDAC inhibitor; E1A and Ras oncogenes; Wnt/beta-catenin/Tcf pathway
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Funding
- Russian Foundation for Basic Research [09-04-00466]
- CRDF-RFBR [RUB1-2868-ST-07/07-04-97154]
- Russian Academy of Sciences (MCB RAS)
- Programs of the Ministry of Education Science FASI [02.512 11.2219]
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HDAC inhibitors induce cell cycle arrest of E1A + Ras-transformed cells accompanied by e2f1 gene down-regulation and activation of Writ pathway Here we show that e2f1 expression is regulated through the Wnt/Tcf-pathway: e2f1 promoter activity is inhibited by sodium butyrate (NaB) and by overexpression of beta-catenin/Tcf The e2f1 promoter was found to contain two putative Tcf-binding elements: the proximal one competes well with canonical Tcf element in DNA-binding assay Being inserted into luciferase reporter vector, the identified element provides positive transcriptional regulation in response to beta-catenin/Tcf co-transfection and NaB treatment. Thus we have firstly demonstrated that e2f1 belongs to genes regulated through Wnt/beta-catenin/Tcf pathway. (c) 2009 Elsevier Inc. All rights reserved
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