Journal
PSYCHOPHARMACOLOGY
Volume 156, Issue 2-3, Pages 165-168Publisher
SPRINGER
DOI: 10.1007/s002130100758
Keywords
N-methyl-D-aspartate; event-related potentials; glutamate; thought disorder; schizophrenia
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Funding
- NIDA NIH HHS [R01 DA03383] Funding Source: Medline
- NIMH NIH HHS [K02 MH01439] Funding Source: Medline
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Rationale: Prepulse inhibition (PPI) of the acoustic startle response (ASR) provides an index of neurophysiological dysfunction in schizophrenia and a method for analyzing underlying neurochemical mechanisms. In rodents, phencyclidine (PCP) and other N-methyl-D-aspartate receptor (NMDAR) antagonists induce schizophrenia-like PPI deficits. Similar effects have recently been observed in a New World monkey species, Cebus apella. Objectives: The present study evaluates the degree to which similar effects are observed in an Old World monkey, M. fascicularis. Methods: An initial study evaluated effects of interstimulus interval on PPI amplitude and latency. A subsequent study evaluated effects of PCP (0.25 mg/kg IM) on PPI of the ASR. Results: Prepulses reduced bout the amplitude and latency of the ASR. PCP treatment prevented both effects without affecting amplitude or latency of the ASR itself. Conclusions: These results demonstrate that both amplitude reduction and latency facilitation are observed during PPI in the monkey and are disrupted by PCP.
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