Journal
TRENDS IN GENETICS
Volume 17, Issue 7, Pages 388-391Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0168-9525(01)02310-1
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The recent successes of genome-wide expression profiling in biology tend to overlook the power of genetics. We here propose a merger of genomics and genetics into 'genetical genomics'. This involves expression profiling and marker-based fingerprinting of each individual of a segregating population, and exploits all the statistical tools used in the analysis of quantitative trait loci. Genetical genomics will combine the power of two different worlds in a way that is likely to become instrumental in the further unravelling of metabolic, regulatory and developmental pathways.
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