Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 5, Issue 4, Pages 452-455Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op010026q
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We report here the scaling up of clinically important dihydropyridine by using a continuous microwave reactor (CMR). We also report the use of aqueous hydrotrope solution as a cheap, safe and green alternative to organic solvent to carry out homogeneous reactions under microwave heating. We have studied different aqueous hydrotrope solutions for the reaction in batch as well as continuous-flow process.
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