Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 402, Issue 2, Pages 324-328Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.10.025
Keywords
HuR; TIA1; TIAR; Alternative Fas splicing; Gene expression control
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Funding
- Ministerio de Ciencia e Innovacion-FEDER [BFU2008-00354]
- Fundacion Ramon Areces, Spain
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The differential expression levels of T-cell intracellular antigens (TIA) and Hu antigen R (HuR) are concomitant with a splicing switch in apoptosis receptor Fas in HCT-116 cells. Thus, overexpression and knockdown of HuR led to Fas exon 6 skipping and inclusion, respectively. These results suggest that the TIA and HuR cellular ratio influences cell-type specific Fas exon 6 splicing pattern. (C) 2010 Elsevier Inc. All rights reserved.
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