Journal
TRAFFIC
Volume 2, Issue 7, Pages 437-448Publisher
WILEY
DOI: 10.1034/j.1600-0854.2001.20702.x
Keywords
excitatory; inhibitory; synapse; AMPA; NMDA; GABA; glutamate; endocytosis; receptor sorting; dynamin; NSF; GABARAP; GRIP; PICK; LTP; LTD; adaptin; clathrin
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Modulation of the strength of synapses is thought to be one of the mechanisms that underlies learning and memory and is also likely to be important in processes of neuropathology and drug tolerance. This review focuses on the emerging role of postsynaptic neurotransmitter receptor trafficking as an essential mechanism underlying the dynamic regulation of synaptic strength.
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