The effects of 2-week ingestion of (-)-hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight

OBJECTIVE: Assessment of the effect of 2-week supplementation with (-)-hydroxycitrate (HCA) and HCA combined with medium-chain triglycerides (MCT) on satiety, fat oxidation, energy expenditure (EE) and body weight (BW) loss. DESIGN: Three intervention periods of 2 weeks separated by washout periods of 4 weeks. Double-blind, placebo-controlled, randomised and cross-over design. SUBJECTS: Eleven overweight male subjects (mean +/- s.d.; age, 47 +/- 16 y; body mass index, 27.4 +/- 8.2 kg/m(2)). INTERVENTION: Subjects consumed three self-selected meals and four iso-energetic (420 kJ) snacks daily with either no supplementation (PLA), 500 mg HCA (HCA) or 500 mg HCA and 3 g MCT (HCA + MCT). Each intervention ended with a 36 h stay in the respiration chamber. RESULTS: There was a significant BW loss during the 2 weeks of intervention (PLA, -1.0 +/- 0.4 kg, P < 0.05; HCA, -1.5 +/- 0.5 kg, P < 0.01; HCA + MCT, -1.3 +/- 0.2 kg, P < 0.001), but this reduction was not different between treatments. 24 h EE (PLA, 11.8 +/- 0.2 MI; HCA, 11.7 +/- 0.1 MJ; HCA + MCT, 11.5 +/- 0.1 Mj), 24 h RQ (0.85 +/- 0.00 in all treatments) and the area under the curve of the appetite-related parameters were not different between treatments. CONCLUSION: Two-week supplementation with HCA and HCA combined with MCT did not result in increased satiety, fat oxidation, 24 h EE or BW loss compared to PLA, in subjects losing BW.