Journal
MOLECULAR GENETICS AND METABOLISM
Volume 73, Issue 3, Pages 224-229Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/mgme.2001.3189
Keywords
trimethylamine; polymorphisms; detoxication enzyme
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Trimethylaminuria (TMAU) results from an accumulation of an excessive amount of unoxidized trimethylamine that is excreted in urine and body secretions. Mutations of the flavin-containing monooxygenase 3 (FMO3) gene (a hepatic phase I drug-metabolizing enzyme) account for the severe recessively encoded form of this condition. We have previously described a number of FMO3 polymorphisms which in vitro exhibit reduced substrate affinity for several FMO substrates. Here we show that three prevalent polymorphisms (E158K, V257M, and E308G) inherited in particular combinations confer a slight decrease in TMA oxidation under normal physiological conditions, which may be clinically silent. With the use of substrate loading or with the interaction of other known modulators of FMO3 activity such as hormonal influences, these genotypes may predispose to mild TMAU. (C) 2001 Academic Press.
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